NIMESULIDE DISPERSIBLE TABLETS 100 MG

NIMESULIDE DISPERSIBLE TABLETS 100 MG:
Batch Size        :    1, 00, 000 Tablets.
Practical Yield    :    97, 000 Tablets.
Usual Packing    :    10 Tablets
FORMULA:

Sr.	Ingredients	Qty required	Overages
	Nimesulide	10.00 Kgs
	Lactose	12.00 Kgs
	Starch	10.00 Kgs
	Sodium Metabisulphite	0.04 Kgs
	Propylparaben	0.04 Kgs
	Starch	3.00 Kgs
	Talcum	0.50 Kgs
	Magnesium Stearate	0.15 Kgs
	Dry mix Banana Flavour	0.25 Kgs
	Sodium Starch Glycolate	1.12 Kgs

MANUFACTURING PROCESS:

1. Sanitize and clean all the equipment as per standard operating procedures.
2. Pass through 40 # mesh sieves ingradients Nimesulide, Lactose, Starch and mix for 15.0 minutes.
3. Prepare the starch paste with ingredients Sodium Metabisulphite, Propylparaben, starch. Add to step (1) and mix till a suitable mass for wet granules is achieved. Pass the wet granules through 8 mm Multimill sieves. Dry the granules to 2.0 % moisture content. Finally shift through 18 # mesh sieves.
4. Lubricate the granules with ingredients Talcum, Magnesium Stearate, Dry Mix Banana Flavour, and Sodium Starch Glycolate.
5. Compress the tablet at the weight of 358 mg per tablet.

TECHNICAL SPECIFICATONS:

1. Average weight         :    358 mg    
2. Thickness            :    4.0 mm
3. Hardness            :    3.0 Kg/ cm²
   
4. Diameter            :    9.5 mm